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no FDA-validated injectable protocol exists

[Crossref] Chalupsky K, Kracun D, Kanchev I, Bertram K, Grlach A (2015) Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase

2018;6(6):CD001190

There is no ramp-up and no dose adjustment mid-cycle

Consistently, downregulation or inactivation of the astrocytic NFkB pathway in EAE model reduces inflammation and improves tissue injury and clinical impairment (100)

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