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Basic and translational research has identified numerous biological mechanisms genetic susceptibility, appetite-regulation pathways, neuroendocrine processes, metabolic adaptation that contribute to weight gain and impede its loss

"Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia." Diabetes , 2013

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( E and F ) Body weight gain in WT ( E ) and Bbs5 / ( F ) mice at 24 and 36 hours after leptin injections