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Important Precautions for Safe Use 15.1 Gradual Dose Escalation to Minimize Side Effects A stepwise titration strategy reduces gastrointestinal intolerance and enhances patient adherence

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The potential explanation for sex differences in the IGF-1 signaling pathway on aging as well as response to other age-delaying interventions is unclear, but unique interactions of candidate pathways and targets with sex hormones could explain in part these disparate effects