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JCI Insight 5 , (2020)
Tirzepatide also targets the GIP receptor, adding a second mechanism that improves insulin sensitivity
The most substantial weight reductions are generally observed between 36-72 weeks of treatment, with the SURMOUNT trials showing continued weight loss throughout the study duration
By activating both pathways simultaneously, tirzepatide supports weight loss through coordinated metabolic signaling rather than appetite suppression alone
Do all semaglutide users experience side effects in the first week
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