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Experimental models have been instrumental in elucidating how perturbations in circadian rhythms may foster a pro-tumorigenic environment, particularly through hormonal, immune, genetic, and epigenetic pathways 38
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Chromatin immunoprecipitation analysis targeting the promoters of FOXO3a and Mt2, utilizing two distinct primer pairs for each promoter, revealed an increase in the acetylation of histone H3K9 [98]
Beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma
Importantly, in active intestinal inflammation, HIF-2 may exert context-dependent effects on ferroptosis susceptibility: even under systemic iron deficiency, local inflammatory cues can paradoxically enhance epithelial iron uptake and/or perturb subcellular iron distribution, thereby increasing the labile iron pool and promoting lipid peroxidation
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