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Many of the new complaints include gastroenterologist assessments and imaging that confirm delayed gastric emptying
The GIP receptor activation adds a complementary mechanism, improving insulin sensitivity and potentially enhancing the metabolic effects beyond what GLP-1 alone achieves
The STEP pediatric trial demonstrated that tirzepatide produced significant weight loss in adolescents ages 1217 compared to placebo, but long-term data in teenagers remains limited
The control group was asked to continue their lifestyle as normal
It has also received approval for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to reduced-calorie diet and increased physical activity
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