However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models
In rare cases, these side effects can be severe, and for some, this may outweigh the potential benefits of the treatment
Efficacy and safety of tirzepatide in type 2 diabetes (SURPASS-5)
N Engl J Med 355(23):24272443
If you do not have one, you can use a plastic bin such as an empty milk jug or laundry detergent container
Side effects are typically mild and may include slight bruising at the injection site, a cooling sensation, or a metallic taste (especially with certain vitamins)