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Adverse drug effects can be due to direct toxicity, for instance as a result of kidney-specific determinants, or indirectly by, e.g., vascular effects or crystals deposition
4,8-10 For all immune-related adverse events, except diarrhea/colitis, the study patients had a longer time to adverse event onset compared with the data in the literature
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Its also important to note that while injections are effective, they should be administered under medical supervision
In addition, some nanoparticles enter cells by interacting with the cell membrane or fusing, which may cause nonspecific cytolysis and thus have cytotoxicity limitations
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