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Novo Nordisk reports up to 13.8% weight loss in people with obesity receiving semaglutide in phase 2 trial [media release]
Semaglutide is a peptide, and the gastrointestinal tract exists in part to dismantle peptides
The peptide's resistance to dipeptidyl peptidase-IV (DPP-IV) proteolysis is achieved through substitution of -methyl-Phe at position 2, which blocks the cleavage of the Tyr1Ala2 bond that normally inactivates native incretins within minutes of secretion
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