Growth hormone receptor upregulation: Animal studies suggest BPC-157 increases growth hormone receptor expression in tendon tissue, potentially amplifying endogenous GH signaling locally rather than elevating circulating GH
Cerebrolysin reduces bloodcerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat
And BPC 157 can inhibit ER stress and increase eNOS -mediated NO product release
By modulating the stress response, they could reduce the neuroimmune triggers that initiate psoriasis flares
Even for topical use, certain groups have a higher risk profile or simply lack the data to make an informed judgment
References Int J Mol Sci (MDPI) Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (2025) PMC/Biogerontology Epitalon increases telomere length in human cell lines through telomerase upregulation Neuroendocrinology Letters (PubMed) Synthetic tetrapeptide Epitalon restores neuroendocrine regulation in senescent monkeys Bull Exp Biol Med (PubMed) Geroprotective effect of epithalamine in elderly with accelerated aging (12-year RCT) Alzheimers Drug Discovery Foundation Epithalamin/Epithalon Cognitive Vitality Report (mechanisms, dosing, safety) JPT Peptide Technologies Peptide Stability: How Long Do Peptides Last