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PMCID: PMC3654245..04r5
Temperature acclimation before drawing doses Cold solution drawn directly from the refrigerator is more viscous than room-temperature solution
User 3 split his 500mcg dose as 250mcg every 12 hours specifically to account for what he cited as a 4 to 6-hour half-life
PMID: 29266896
And in the 80s it increased to every three months, which is still what they use today
Bajerska, J., Jeszka, J., Czapka-Matyasik, M., and Kostrzewa-Tarnowska, A
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