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Combined with the way it totally flattened out post-meal glucose levels, exendin-4 seemed to him like a blunter tool than what drugmakers should ultimately be shooting for

Remember that weight can fluctuate due to factors like water retention, so dont be discouraged by minor changes

Published 2017 Dec 22 Tahara Y, Hirota M, Shima K, et al

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Manufacturer expiration dates vs reality What expiration dates mean: Conservative estimate of guaranteed potency Usually based on accelerated stability testing Designed to ensure 90-100% potency through date Regulatory and liability considerations Why stated dates are conservative: Expensive to test long-term (years) Manufacturers want safety margin Better to underestimate than overestimate Varies by company (research chemicals vs pharma) Research peptide "expiration": Often no formal expiration date COA (Certificate of Analysis) shows testing date General rule: 2 years from COA date if frozen 6-12 months from COA if refrigerated Real-world peptide longevity: Frozen peptides often remain 80%+ potent at 3-5 years Refrigerated peptides good 12-18+ months if properly stored Much depends on storage conditions and handling When to trust peptides past "expiration": Stored frozen continuously: Very likely still good Stored refrigerated: Probably good if within 1-2 years Room temp storage: Don't trust past weeks Visual inspection passes (see below) COA relatively recent (within 2-3 years) When to discard despite date: Visible discoloration or changes Exposed to heat or temperature extremes Stored at room temperature for extended period Seal broken (contamination risk) Smell or visual contamination Shelf life after reconstitution (liquid peptides) Reconstituted peptides have much shorter lifespans

These genes are LRRK2 (leucine-rich repeat kinase 2), alpha synuclein, parkin, VPS35 (vacuolar protein sorting 35), DJ-1 (protein deglycase) and PINK1 (phosphatase and tensin homologue-induced kinase1)