Funding The authors declare that no financial support was received for the research and/or publication of this article
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The co-primary endpoints, percent change in body weight from baseline and proportion of patients achieving 5% weight loss, were identical to those of SURMOUNT-1, as were the two estimands: the TRE (which included all patients who were randomized) and the efficacy estimand (which included randomized patients who remained on the study treatment for the entire efficacy assessment duration of the trial)
B12 treatment may also be part of care for certain forms of anemia caused by deficiency
Presented for research literature review only Atoyebi W et al
[61,63] have reported that the small molecule antidepressant drug amitriptyline is capable of binding to the BDNF target Trk receptor, induce receptor dimerization, and autophosphorylation