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NICE notes that pernicious anaemia is the most common cause of Vitamin B12 deficiency in those aged 40-70, with an average onset age of 60 in white people and 50 in black people, although it can affect black women at a younger age

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Supplementation of 500 mg/d for 4 weeks downregulated the HPA axis, altered the typical pattern of ACTH and cortisol change, and reduced immune response activation in Mg-supplemented rugby players (Dmitrainovi 2016) Omega-3 Fatty Acids 1 to 2 g/d (Jahangard 2019, Kiecolt-Glaser 2011) Daily 1,000 mg omega-3 supplementation for 8 consecutive weeks positively influenced psychological and physiological markers of occupational burnout, including lowering morning cortisol (Jahangard 2019)

Neuroprotective Effects: Reduces oxidative stress and supports cognitive resilience

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