Diarrhea and headache
The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
Its important to discuss all medications, supplements, and treatments you are currently taking with your healthcare provider to identify potential interactions
Prior authorization : Some plans need approval before starting certain injections
Prepared solutions should be handled according to your laboratory SOPs and protected from repeated temperature cycling
B12 is safe on its own, but a few conditions call for extra care, which is why a provider reviews your history before treatment: Leber's hereditary optic neuropathy, a rare inherited eye condition, where certain forms of B12 may be a concern for the optic nerve