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11d and 11g) Given the differentiation in conformational dynamics of Cagri-bound versus rAmy-bound to CTR or AMYRs and the likely role that the P37 Cagri played in these differences, we also assessed in the assay an analogue of Cagri that contained a P37Y substitution

( C ) Insulin and glucagon colocalization in the islet

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2015;308:G206G216

This study reports an AMP-independent mechanism for glucose sensing by AMPK through the lysosomal pathway