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Compounding gastrointestinal side effects (severe nausea, vomiting, dehydration), increased hypoglycemia risk, unpredictable drug-drug interactions, and complete absence of safety data
A recent meta-analysis evaluating the effects of GLP-1 RAs on depression found that these agents did not increase the risk of depression and may reduce depression scores [46]
Effects of short-term exenatide treatment on regional fat distribution, glycated hemoglobin levels, and aortic pulse wave velocity of obese type 2 diabetes mellitus patients
10.1038/nrgastro.2010.213 26
In the past decade, drug repositioning become very important in the field of cancer therapy
On 19 March 2026, the FDA approved a higher-dose formulation of semaglutide, Wegovy HD, at 7.2 mg for once-weekly subcutaneous administration
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