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94,95 In COPD, epithelial to mesenchymal transition (EMT) which is associated with airway remodelling and obliteration is activated by canonical pathways such as TGF-, which induce expression of nuclear transcription factors pSMAD2/3 and reduced inhibitory SMAD6/7 expression
10.1038/sj.onc.1202707 97 TanakaT.KondoS.IwasaY.HiaiH.ToyokuniS
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