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For patients who are not candidates for GLP-1-RAs and have a contraindication to topiramate (e.g., nephrolithiasis) and/or phentermine (e.g., uncontrolled hypertension), monotherapy bupropion or bupropion/naltrexone might be considered, though little data exists regarding its efficacy after bariatric surgery

"This could create a niche where these agents outperform pure GLP-1RAs," says Nadolsky

In Study 2, participants viewed the person who regained weight after stopping the GLP-1RA medication similarly on most measures to the individual who regained weight after stopping diet and exercise

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Anti-inflammatory properties: Reduces chronic low-grade inflammation, which causes skin thinning, loss of suppleness, and age-related tissue breakdown

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