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GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they promote insulin release only when blood glucose levels are elevated

& Sharpe, H

Subcutaneous fat is less affected, which is why tesamorelin does not produce the lean, deflated look associated with caloric restriction

Unlike Semaglutide (GLP-1 only) or Tirzepatide (GLP-1 + GIP), Retatrutide activates three hormone pathwaysGLP-1, GIP, and glucagonleading to enhanced fat loss and energy expenditure

However, 15 to 60% of this can be lean mass, including muscle

Consult a healthcare professional before any consideration of use