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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

Proc Natl Acad Sci 91(1):210214 Zheng Y, Cantley LC (2019) Toward a better understanding of folate metabolism in health and disease

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The first is through the diet, utilizing the CDP-choline (Kennedy) pathway

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