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Lack of CYP2D6 activity is an autosomal recessive trait that occurs in 5%10% of Caucasians of European descent but occurs in only 1%2% of those of Southeast Asian ancestry

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The bulk solution is compounded in water-for-injection at controlled pH under low-actinic, light-protected conditions, sterile-filtered through 0.22 m membrane and filled aseptically into amber-glass ampoules under ISO Class 5 air with light excluded throughout

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Distinct experimental groups were observed under controlled conditions over an extended evaluation period

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