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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
What Does the Research Say About GLP-1s and PMOS
These are label statements, and they are presentation-specific in their details
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Free Radical Biology and Medicine , 67, 396-407
