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Energy Expenditure: Metabolic rate measurements, activity levels
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Retatrutide (Retara), a triple GIP/GLP-1/glucagon agonist, produced the highest mean weight loss in clinical trials (24.2% at 48 weeks)
Sci Rep 14 , 13862 (2024)
For a medication class, 20 years is a short window for understanding long-term safety and effects
The eligibility study reported by Fierce Healthcare underscores how large this overlap is: the semaglutide-eligible population it identified included tens of millions of adults covered by Medicare and Medicaid, many of whom qualify through diabetes or cardiovascular indications rather than weight criteria alone
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