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In CD4 T cells, extracellular lactate not only inhibits their migratory capacity, but also contributes to their conversion to a proinflammatory Th17 phenotype, characterized by increased expression of cytokines such as IL-2 and IL-17 [116, 117]
Genetic variants in B12 metabolism pathways (e.g., MTHFR, MTR, MTRR genes) can influence how efficiently your body processes and utilizes B12, potentially affecting both side-effect risk and clinical benefit
This can cause irregular heartbeats, which may be dangerous, especially in people with existing heart issues or those taking other QT-prolonging drugs
