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Your body evolved sophisticated mechanisms to prevent starvation
When GLP-1 medications further slow stomach emptying, digestive symptoms may temporarily intensify during dose escalation
Obese persons are likely responsible for an outsized percentage of sales by volume, and its not uncommon to meet someone with obesity who consumes fast food twice a day
Prioritizing healthy foods, exercising regularly, and getting enough sleep all cause your natural GLP-1 levels to rise temporarily (only for a couple of minutes, as opposed to GLP-1 medications, which last for a week) (5, 6, 7)
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However, some data suggests that tirzepatide dual mechanism may actually reduce GI side effects compared to pure GLP-1 agonists, because the GIP component appears to have a moderating effect on nausea
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