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Enhanced efficacy (via altered receptor trafficking and/or cross-talk) and/or potency (via entropic/avidity effects) may be obtained through possible multivalent receptor interactions in cells co-expressing the GLP-1R and the FGF21R (klotho/FGFR1c complex)
Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute major depressive episodes Psychiatry Res 1996
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doi:10.1177/2472555218812821 Izzo LT, Trefely S, Demetriadou C, et al
- Ti to h thn kinh v trao i cht: Vitamin B6 bo v thn kinh chng li glutamate c hi, trong khi Magie h tr chuyn ha thc n thnh nng lng v cc phn ng sinh ha
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
