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Additionally, patients on dual therapy would face doubled medication costs, doubled adherence burden, and no clinical evidence of superior outcomesmaking the risk-benefit calculation clearly unfavorable compared to optimizing a single agent

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Given the results from recent studies, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend that patients with T2D and clinical cardiovascular disease (CVD) with inadequate glucose control despite treatment with metformin should receive an SGLT2 inhibitor or GLP-1 receptor agonist

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