wrote the first draft
Potential Effects on Food Preferences: Some studies suggest that GLP-1 receptor agonists like semaglutide might even influence food preferences, potentially reducing cravings for high-fat and high-sugar foods
Cheese: Cheese often goes unnoticed, but it is high in fat and should be limited or avoided
In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research
The inclusion of glucagon agonism was initially counterintuitive, but research suggests that when combined with GLP-1 and GIP activity, the net metabolic effect may be beneficial rather than hyperglycemic
doi: 10.1016/j.chom.2010.08.004 36 KleessenBKroesenAJBuhrHJBlautM