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Furthermore an inflammatory status, as seen in pathologies such as type 2 diabetes, might compromise the gut mucosal permeability, leading to the exposure of intestinal EECs to luminal LPS, and a TLR4-mediated release of GLP-1 (229)

GLP-1 GLP-1(-1) 1 GLP-1DPP-4GLP-1DPP-41GLP-120202GLP-1GLP-1 2023418GLP-1/GIP1: GLP-1GLP-1GIPGLP-1GIPGLP-12024316243 GLP-1 () GLP-1 () GLP-1 () 1GIP/GLP-1GIPKGLP-1LGLP-1GIPGLP-1(1) GIPGLP-1 7GIPGLP-1()32GIPGLP-1(2) 15mg12.5mg415mg15mg42.5mg115mg 1mgSURPASS-2405 mg10 mg15 mg1 mg HbA1c5 mg -2.09%10 mg -2.37%15 mg -2.46% -1.86%31mg(3)1mg5mg1mgHbA1c 5 mg -7.8 kg10 mg -10.3 kg15 mg -12.4kg1mg -6.2kgHbA1c31mg(4)1mg5mgHbA1c1mg 15 mg 63.6%10 mg 68.7%15 mg 68.9% 64.2% 1722%18% 1316%12% 610%8%(5)54 mg/dL 0.6%5 mg0.2%10 mg1.7%15 mg 0.4% GLP-1GLP-1 GLP-1 GIP/GLP-1

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