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Moreover, it has been observed that cyclic GSH, which is less sensitive to the effects of several degradative enzymes, appears to have toxic activity on cancer cell lines 87

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Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

In: Robertson RP, editor

These modifications extend its half-life from approximately 10 hours (endogenous IGF-1) to 2030 hours and reduce its binding affinity to IGF-binding proteins (IGFBPs), increasing bioavailability