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Modern research emphasizes that BPC-157 is most effective when administered at pharmaceutical-grade purity under medical supervision to ensure proper dosing and monitoring

This equates to anything higher than about 60C (140F)

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The trade-off is that daily injections require more discipline and create more opportunities to miss doses, which can reduce effectiveness

J Cutan Pathol 44(5):420432

doi: 10.1136/archdischild-2013-303718 [9] Frey N, Bodmer M, Bircher A et al