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Both extracellular and cytoplasmic regions of active GHSR showed significant structural differences compared to the inactive GHSR in the crystal structure reported before 34

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Cascella R, Evangelisti E, Zampagni M, Becatti M, D'Adamio G, Goti A, Liguri G, Fiorillo C, Cecchi C

Oxidative stress and accelerated aging are the clearest targets, since glutathione is the front-line molecule that neutralizes free radicals before they damage mitochondria and DNA