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97 In glioblastoma cells with aberrant epidermal growth factor receptor (EGFR) signaling, PFK1 undergoes acetylation at the K395 site and translocates to the plasma membrane, recruiting and binding with p85, leading to sequential activation of PI3K/AKT, PFK2, and PFK1

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Weeks 9-12 : The dosage is raised to 1.0 mg weekly