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Keywords : ferroptosis, temporomandibular joint osteoarthritis, knee osteoarthritis, mechanism, iron More than 22 percent of adults over the age of 40 suffer from osteoarthritis (OA), a degenerative joint disease which causes pain, limited movement, as well as stiffness in the affected joints [1-3]

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GLP-1 receptors are widely expressed in myocardial and vascular systems 34 , and activation of these receptors may reduce cardiovascular risk by enhancing endothelial nitric oxide production 35,36 , modulating vascular tone, and reducing epicardial adipose tissue volume 37,38