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A thorough personal and family medical history should identify contraindications to either therapy, including history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (contraindications to GLP-1/GIP therapy), and history of breast cancer, endometrial cancer, unexplained vaginal bleeding, active liver disease, or thromboembolic disease (potential contraindications to HRT)

doi: 10.1016/j.biopha.2023.115962 218 ZhuHHuSLiYSunYXiongXHuXet al

The cardiovascular profile of semaglutide has been extensively studied in landmark trials

The temperature must be kept at a consistently low level in order to preserve the properties of the bacteriostatic water that make it suitable for reconstituting peptides

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However, achieving and maintaining this degree of weight reduction through lifestyle modification alone is challenging for most patients, creating an urgent need for effective pharmacological therapies