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The SURMOUNT-5 data on waist circumference is also clinically meaningful: research has shown that each 5-centimeter increase in waist circumference corresponds to a 7 to 9 percent increase in mortality risk, making the 5.4-centimeter additional reduction with tirzepatide a potentially significant benefit.1 That said, semaglutide remains highly effective and is still the right choice for many patients, depending on insurance coverage, cost, tolerance, and individual response

Notini AJ, McManus JF, Moore A, Bouxsein M, Jimenez M, Chiu WS, et al

Diabetes 50 , 25302539 (2001)

doi: 10.3389/fendo.2024.1440182 Received 29 May 2024 Accepted 26 August 2024 Published 18 September 2024 Volume 15 - 2024 Edited by Kuan-Hao Tsui, Kaohsiung Veterans General Hospital, Taiwan Reviewed by Xiuliang Dai, Changzhou Maternal and Child Health Care Hospital, China Rui Yang, Peking University Third Hospital, China Updates Copyright 2024 Zhao, Liu, Zhang, Sun, Zeringue, Meng and Ma

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