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Obesity and PAD, including chronic limb-threatening ischaemia, are linked to increased inflammation, poor blood vessel function, insulin resistance, oxidative stress and faster hardening of the arteries, said study co-author Akiva Rosenzveig, a cardiology fellow at the Cleveland Clinic

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When scaling protocols from rodent data to higher-order models, researchers should apply allometric correction factors rather than relying on raw values from a peptide half-life chart calibrated to one species

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