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TZDs uniquely target insulin resistance, which is a core physiologic defect in T2D, and significantly improve glucose control
Noteworthy, lower efficacy of obesity management medications in patients with T2D is a well-documented and established finding
10.2337/db10-0504 163
Cigna may require step therapy, meaning patients must try a less expensive medication such as Contrave before the insurer approves a GLP-1 agonist
Drucker, D.J., 2024
However, when we get more than the minimum amount of each nutrient we need, we experience sensory-specific satiety and our cravings subside
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