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DOX is a highly toxic molecule and induces drug resistance due to the overexpression of ABCB1 efflux pump and other related proteins 127

Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells

Most patients naturally eat 1,5002,000 calories daily on therapeutic tirzepatide doses (7.515 mg) without conscious restriction

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Similarly, Gan & Lee is progressing GZR18, a biweekly injectable, as well as GLP-1 + insulin candidates