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Finally, the study relied on self-reported dietary intake, which can be subject to recall bias, although efforts were made to minimize this through regular monitoring and food records

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Our study revealed that SKN-1 is induced by the accumulated fat in all three sterile mutants, irrespective of the lifespan phenotype, consistent with the known role of SKN-1 in responding to lipid toxicity 16

In order to investigate the roles of these proteins in the ubiquitination cascade, we performed in-vitro ubiquitination assays using the purified c-Jun bound DDD-Ube2e2-COP1 complex (Fig

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Glutathione also works with glutathione peroxidase, an antioxidant enzyme that helps convert hydrogen peroxide and lipid peroxides into less reactive substances