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10.1016/j.ijpharm.2015.05.027 111 MichalakZ.LebrunA.Di MiceliM.RoussetM.-C.CrespelA.CoubesP.et al

In rare therapeutic cases, they may contribute to rapid weight changes, but not commonly in regular dosing

Hypoxia-driven immune escape in the tumor microenvironment

Supplementation is unnecessary if parenteral therapy repletes serum levels, but individual assessment is advised

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Its stability in vitro is limited, with a half-life of roughly 15 minutes, but in vivo it may form complexes with carrier proteins or exist as part of a larger precursor molecule to resist degradation

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