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Most studies from this analysis used doses ranging from roughly 125600 mg daily for 13 months
Factor #1: Weight loss restores ovulation (sometimes very quickly) The mechanism works like this: Excess body fat produces estrogen and disrupts normal ovulation, while fat cells also produce inflammatory compounds that interfere with reproductive hormones
As the name implies, water-soluble vitamins dissolve in water
These generally subside as the body adjusts to the medicine
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PMID 24571751
Gradual escalation gives the GI system time to adapt
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