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On the other hand, because semaglutide can affect the balance of certain hormones and proteins in the blood, it could theoretically influence clot formation in ways not yet fully understood

Shapiro IM, Adams CS, Freeman T, Srinivas V

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However, reduced side-effects at lower doses make it likely there are also reduced therapeutic effects

The additional glucagon receptor activation is hypothesised to further increase energy expenditure

Low GH promotes visceral fat accumulation, and elevated visceral fat further suppresses GH release through increased free fatty acid flux and inflammatory signaling