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Beyond malignant epithelial cells, the TME encompasses hypoxic niches, infiltrating immune cells, stromal fibroblasts, and an aberrant extracellular matrixall of which converge to drive resistance to standard therapies, including brachytherapy [27, 28]
In one-way sensitivity analysis, the ICER remained within 4.30 million to 6.30 million/QALY in the non-T2D cohort and 5.74 million to 8.44 million/QALY in the T2D cohort when key parameters were varied, and no plausible variation changed the direction of incremental costs and QALYs
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L., McIvor, R
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