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But there are exceptions: Compounding pharmacies can fill the gap when a drug is in shortage

CJC-1295 tells the pituitary to make more growth hormone

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The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising. In another study the muscle fibers of 27-month old rats old age for rats that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging

The difference that matters most today, though, is regulatory: semaglutide is an approved medicine with years of real-world data, while retatrutide is still an investigational compound being studied in clinical trials