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Inhibition of TGR5 mediated effects by H 2 S is due to inhibition of PI hydrolysis (Figure 9)

Nature 430 : 165167 Challis BG et al

A study showed that changes in postprandial GLP-1 RA levels were positively correlated with local cerebral blood flow to the left dorsolateral prefrontal cortex and the hypothalamus, which is known to be associated with satiety and the control of food intake [5]