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Concurrently, DRP-104, the prodrug of DON, has been observed to promote the polarization of tumor-associated macrophages (TAMs) to the M1-TAMs phenotype

For histological analysis, the femoral and tibial condyles were fixed in 10% neutral buffered formalin, decalcified with 20% EDTA, embedded in paraffin, and sectioned into 5-m thick frontal slices

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Glutathione IV therapy involves the administration of this potent antioxidant directly into the bloodstream, offering a range of potential benefits for the body