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Glycogen synthase kinase-3 is a crucial downstream effector of remifentanil-induced cardioprotection, serving as a critical checkpoint that stabilises mPTP closure and suppresses apoptotic signalling, promoting glycogen synthesis [145, 201]
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Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years
A third caller, a 33-year-old woman, reported getting semaglutide at a spa but didn't know the dose
The answer was Tirzepatide a dual agonist targeting both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), another gut hormone that amplifies insulin release
Unlike the occasional craving, food noise feels like constant, intrusive thoughts about eating whether youre physically hungry or not
