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J Am Soc Nephrol (2011) 22(1):10412

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3.7 Endoplasmic reticulum stress ERS refers to the disruption of normal functioning and homeostasis within the endoplasmic reticulum (ER) of cells, resulting from the accumulation of unfolded or misfolded proteins and an imbalance between protein folding capacity and protein load

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Based on the enhanced permeability and retention effect, the nanoparticles can accumulate in the tumorous tissue 33,34